3. Cytogenetic and Molecular Abnormalities.
نویسندگان
چکیده
منابع مشابه
Cytogenetic and molecular abnormalities in chronic myelomonocytic leukemia.
Chronic myelomonocytic leukemia (CMML) is a clonal stem cell disorder associated with peripheral blood monocytosis and an inherent tendency to transform to acute myeloid leukemia. CMML has overlapping features of myelodysplastic syndromes and myeloproliferative neoplasms. Clonal cytogenetic changes are seen in ~30%, whereas gene mutations are seen in >90% of patients. Common cytogenetic abnorma...
متن کاملCytogenetic abnormalities in a plasmacytoma.
By SEnclo MANCINELLI, JOHN R. DURANT, AND WILLIAM J. HAMMACK T SOMEWHAT CONSISTENT cytogenic changes in patients with multiple myeloma have recently been reported. Houston et al.,’ using phytohemagglutinin (PHA) stimulated peripheral blood cells, observed abnormal chromosomes in fifteen of twenty-four patients. The abnormal chromosomes were as large or larger than normal A group members with ce...
متن کاملMolecular cytogenetic dissection of human chromosomes 3 and 21 evolution.
Chromosome painting in placental mammalians illustrates that genome evolution is marked by chromosomal synteny conservation and that the association of chromosomes 3 and 21 may be the largest widely conserved syntenic block known for mammals. We studied intrachromosomal rearrangements of the syntenic block 3/21 by using probes derived from chromosomal subregions with a resolution of up to 10-15...
متن کاملMolecular and cytogenetic abnormalities in acute myeloid leukemia: review and case studies.
OBJECTIVE To study the frequency of mutations that may lead to a good or bad prognosis, as well as their relation with the karyotype and immunophenotype in patients with acute myeloid leukemia. METHODS Thirty samples of patients with acute myeloid leukemia were studied, in which FLT3-ITD, FLT3-TKD and NPM1 mutations were investigated. All samples were submitted to immunophenotyping and 25 to ...
متن کاملCombined Use of Cytogenetic and Molecular Methods in Prenatal Diagnostics of Chromosomal Abnormalities
AIM The aim of prenatal diagnostics is to provide information of the genetic abnormalities of the fetus early enough for the termination of pregnancy to be possible. Chromosomal abnormalities can be detected in an unborn child through the use of cytogenetic, molecular- cytogenetic and molecular methods. In between them, central spot is still occupied by cytogenetic methods. In cases where use o...
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ژورنال
عنوان ژورنال: Nihon Naika Gakkai Zasshi
سال: 2011
ISSN: 0021-5384,1883-2083
DOI: 10.2169/naika.100.1801